目的和方法 :观察腹腔注射 (i.p) 2mg kg和 10mg kg芦沙坦 (losartan)对大鼠股动脉血压 (aterialbloodpressure ,AP)和心率 (heartrate,HR)的影响以及与缰核 (Hb)神经元活动的关系。用玻璃微电极记录内侧缰核 (MHb)、外侧缰核(LHb)神经元单位放电活动 ,观察 10mg kg芦沙坦对其放电频率的影响。结果 :2mg kg芦沙坦对大鼠AP和HR无明显影响 ;(10mg kg芦沙坦可显著降低大鼠动脉血压 ,但对心率无明显影响。 10mg kg芦沙坦可使LHb内 6 6 6 6 % 12 18)神经元单位放电频率增加 ,使MHb内 6 1 90 % (13 2 1)神经元单位放电频率减少。结论 :10mg kg芦沙坦可明显地降低大鼠AP ,但 2mg kg芦沙坦对AP无明显影响 ;10mg kg芦沙坦可兴奋LHb和抑制MHb,产生降压效应 PURPOSE AND METHODS: The effects of intraperitoneal injection of 2 mg kg and 10 mg losartan on aterial blood pressure (AP) and heart rate (HR) The relationship of activities. Glass microelectrodes were used to record the firing activity of MHb and LHb neurons. The effects of 10 mg kg of losartan on the discharge frequency were observed. RESULTS: Losartan at a dose of 2 mg showed no significant effect on AP and HR in rats (10 mg of losartan significantly reduced arterial blood pressure, but had no effect on heart rate. 6% 12 18) The discharge frequency of neurons increased, which reduced the discharge frequency of 6 1 90% (13 2 1) neurons in MHb. CONCLUSION: Losartan at a dose of 10 mg significantly reduces AP in rats, but there is no significant effect of 2 mg kg of losartan on AP; 10 mg kg of losartan excites LHb and inhibits MHb, resulting in a hypotensive effect