目的：研究缺氧引起的血管收缩是否与血管内皮细胞释放内皮素（ＥＴ）有关．方法：９５％Ｏ２＋５％ＣＯ２混合气体换成９５％Ｎ２＋５％ＣＯ２引起急性缺氧，描记猪基底动脉环的张力变化．结果：在基础张力条件下和由ＥＴ３ｎｍｏｌ·Ｌ－１引起收缩时，缺氧分别使基底动脉张力增加０２１ｇ±００８ｇ和０２４ｇ±００９ｇ．当ＥＴ浓度从１００ｎｍｏｌ·Ｌ－１增加到３００ｎｍｏｌ·Ｌ－１时，动脉的张力不进一步增加，此时急性缺氧仍使张力进一步增加０１６ｇ±０１０ｇ．过氧化氢酶８００，２４００ｋＵ·Ｌ－１明显降低缺氧引起的收缩，抑制率分别为３３％±７％和４７％±９％．结论：缺氧引起的血管收缩与内皮细胞释放过氧化氢有关 Objective: To investigate whether hypoxia-induced vasoconstriction is associated with the release of endothelin (ET) from vascular endothelial cells. Methods: Acute hypoxia was induced by changing 95% O2 + 5% CO2 mixed gas into 95% N2 + 5% CO2, and the changes of the tension of pig basilar artery rings were described. RESULTS: Hypoxia increased basilar artery tension by 021g ± 008g and 024g ± 009g, respectively, under basic tension and induced by ET3nmol·L-1. When the concentration of ET increased from 100nmol·L-1 to 300nmol·L-1, the tension of the artery did not increase further. At this time, the acute hypoxia increased the tension further by 0.16 ± 0.10g. Catalase 800,2400 kU · L-1 significantly reduced hypoxia induced contraction, the inhibition rates were 33% ± 7% and 47% ± 9%. Conclusion: Hypoxia-induced vasoconstriction is associated with the release of hydrogen peroxide from endothelial cells