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目的：分析卵巢成熟性囊性畸胎瘤恶变的临床病理学特征及其与人类乳头瘤病毒感染的关系。方法：回顾性研究了１４例卵巢成熟性囊性畸胎瘤恶变临床及病理学特征，并且应用ＰＣＲ技术对其中７例的瘤体组织及宫颈组织进行了人类乳头瘤病毒检测。结果：１４例卵巢畸胎瘤恶变病例发病年龄为３０～８２岁（平均６１．７岁），组织学类型包括鳞状细胞癌（１１例）、腺癌、甲状腺乳头状腺癌及甲状腺类癌（各１例）。人类乳头瘤病毒检测没有发现阳性病例。结论：卵巢成熟性囊性畸胎瘤恶变是一种少见的病变，发病年龄以绝经后妇女为主，组织学类型以鳞状细胞癌最为多见，未发现ＨＰＶ感染与其的关系。
OBJECTIVE: To analyze the clinicopathological features of mature ovarian cystic teratoma and its relationship with human papillomavirus infection. Methods: A retrospective study of 14 cases of ovarian mature cystic teratoma malignant transformation clinical and pathological features, and the application of PCR technology in which 7 cases of tumor tissue and cervical tissue of human papillomavirus detection. Results: The age of onset of malignant ovarian teratoma in 14 cases was 30-82 years (average 61.7 years). The histological types included squamous cell carcinoma (11 cases), adenocarcinoma, thyroid papillary adenocarcinoma and thyroid carcinoid (1 in each case). Human papillomavirus test found no positive cases. Conclusion: Malignant ovarian cystic teratoma is a rare disease, the age of onset is mainly postmenopausal women, histological types of squamous cell carcinoma is the most common, no relationship between HPV infection and its discovery.