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目的：探讨喉癌向周围组织浸润发展的方式。方法：应用抗癌基因Ｐ５３单克隆抗体（ＤＯ－１）对１９例喉癌、癌旁和相对正常组织进行免疫组织化学染色。结果：Ｐ５３蛋白阳性物质位于肿瘤细胞核和转化的细胞核内。喉癌的表达率为７３．６８％。癌旁的表达率为３６．８４％，且３～５个阳性细胞位于上皮基底部的细胞核内，呈局灶性、跳跃性表达。结论：喉癌细胞向周围组织浸润方式是跳跃性的，因此为了达到手术治愈目的，喉癌切除术的安全缘至少１ｃｍ。
Objective: To explore the way of laryngeal carcinoma infiltration to the surrounding tissue. Methods: Immunohistochemical staining was performed on 19 cases of laryngeal carcinoma, paracarcinoma and normal tissues using the anti-oncogene P53 monoclonal antibody (DO-1). Results: The P53 protein positive substance was located in the nucleus of the tumor and the transformed nucleus. The expression rate of laryngeal cancer was 73.68%. The expression of para-cancer was 36.84%, and 3 to 5 positive cells were located in the nucleus of the basal part of the epithelium, showing focal and leaping expression. CONCLUSIONS: Laryngeal cancer cells infiltrate the surrounding tissues in a leapfrog manner. Therefore, in order to achieve the goal of surgical cure, the safety margin of laryngeal cancer resection is at least 1cm.