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目的为了探讨孕期高氟摄入对新生儿行为神经发育的影响,评价氟对神经发育的毒性。方法随机抽取饮水型高氟地区黑龙江省肇州县出生的正常足月新生儿,根据孕妇当地饮水含氟量的不同分为高氟组及对照组,采用氟离子选择电极法测定孕妇产前尿氟,新生儿行为神经发育评分为效应指标。结果高氟组孕妇尿氟水平明显增高,高氟组与对照组新生儿行为神经发育总评分,主动肌张力、行为能力项中的非生物视定向反应、生物视听定向反应评分上差异有显著意义(P<0.05)。结论氟是一种神经发育毒物,孕母生活环境的高氟摄入对新生儿行为神经发育可产生不良影响。
Objective To explore the influence of high fluoride intake during pregnancy on behavioral neurogenetic development in neonates and to evaluate the toxicity of fluorine to neurodevelopment. Methods Normal full-term newborns born in Zhaozhou County, Heilongjiang Province, drinking-water high-fluoride areas were randomly divided into high fluoride group and control group according to the fluoride content of drinking water in pregnant women. The prenatal urine was measured by fluoride ion selective electrode Fluoride, neonatal behavioral neurological development score as an effect index. Results The levels of urinary fluoride in high fluoride group were significantly higher than those in high fluoride group. There were significant differences in scores of newborn neurobehavioral development, active muscle tone and behavior abilities in non-biological visual acuity and biological visual response scores (P <0.05). Conclusion Fluoride is a neurodevelopmental toxic substance. The high fluorine intake in the living environment of pregnant mothers may have adverse effects on the behavioral and neurogenetic development of neonates.