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对妊高征患者红细胞膜过氧化脂质（ＬＰＯ）含量、超氧化物歧化酶（ＳＯＤ）活性、Ｎａ~＋Ｋ~＋－ＡＴＰ酶活性及膜内面 Ｃａ~(２＋)结合能力的变化进行研究。方法：检测 １９名正常孕妇， １９例妊高征患者红细胞膜 ＬＰＯ、ＳＯＤ、Ｎａ~＋－Ｋ~＋－ＡＴＰ酶活性（比色法）及膜内面Ｃａ~(２＋)结合力（原子吸收法）。结果：（１）妊高征组红细胞膜ＬＰＯ含量明显高于正常孕妇组（Ｐ＜０．００１）。（２）妊高征组红细胞膜ＳＯＤ活性明显低于正常孕妇组（Ｐ＜０．００１）。（３）妊高征组红细胞膜Ｎａ~＋－Ｋ~＋－ＡＴＰ酶活性明显低于正常孕妇组（Ｐ ＜ ０．０１）。（４）妊高征组红细胞膜内面的Ｃａ~（２＋）结合量明显低于正常孕妇组（Ｐ＜０．０１）。结论：妊高征患者红细胞膜脂质过氧化增强和抗氧化能力减低，两者间平衡破坏。红细胞膜Ｎａ~＋Ｋ~＋ＡＴＰ酶活性及膜内面Ｃａ~(２＋)结合能力的降低提示膜离子运输功能失常。
The contents of peroxidative lipid (LPO), superoxide dismutase (SOD), Na ~ + K ~ + -ATPase activity and Ca ~ (2+) binding capacity of erythrocyte membrane in patients with PIH were studied. Methods: The activities of LPO, SOD, Na ~ + -K ~ + -ATPase (colorimetric method) and Ca ~ (2+) on the inner membrane of 19 normal pregnant women and 19 cases of PIH were detected by the method of atomic absorption ). Results: (1) The content of LPO in erythrocyte membrane of PIH group was significantly higher than that of normal pregnant women (P <0.001). (2) SOD activity of erythrocyte membrane in PIH group was significantly lower than that in normal pregnant women (P <0.001). (3) The Na ~ + -K ~ + -ATPase activity of erythrocyte membrane in PIH group was significantly lower than that in normal pregnant women (P <0.01). (4) The content of Ca2 + in the surface of erythrocyte membrane in PIH group was significantly lower than that in normal pregnant women (P <0.01). Conclusion: The erythrocyte membrane lipid peroxidation and anti-oxidative capacity of patients with PIH are decreased, and the balance between them is destroyed. The activity of Na ~ + K ~ + ATPase in erythrocyte membrane and the decrease of Ca ~ (2+) binding ability in membrane surface suggest the dysfunction of membrane ion transport.