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目的探讨肺炎链球菌肺炎致缺铁性贫血是否真正需要补铁和补铁治疗的时机,贫血程度与补铁疗效及抗感染疗程之间的内在关系。方法 93例肺炎链球菌肺炎致轻-中度缺铁性贫血病人按缺铁性贫血程度分为轻度组51例,中度组42例,予以抗感染及抗感染加补铁。轻度组中抗感染加补铁治疗27例(补铁亚组),单纯抗感染治疗24例(对照组);中度组中抗感染加补铁亚组23例,对照组19例。观察各组的抗感染疗程、感染好转后贫血指标的变化情况。结果轻度组中抗感染加补铁亚组达到临床相同节点(符合临床好转评价指标)的疗程为(9.4±2.2)d,单纯抗感染组的疗程为(10.0±2.0)d,差异无统计学意义(P>0.05),2亚组治疗后3、7、14d贫血指标比较差异无统计学意义(P均>0.05)。中度组抗感染加补铁亚组达到相同临床节点的疗程为(11.3±3.9)d,单纯抗感染组的疗程为(10.9±4.0)d,二者比较无统计学差异(P>0.05),治疗后3、7、14d贫血指标比较无统计学差异(P>0.05)。结论未发现肺炎链球菌致轻中度缺铁性贫血补铁干预有益;未发现补铁治疗对抗感染疗程有明显的影响。
Objective To investigate whether pneumococcal pneumonia caused by iron deficiency anemia really need iron and iron supplementation of the timing of the degree of anemia and iron supplementation and the relationship between anti-infective therapy. Methods Seventy three patients with mild or moderate iron deficiency anemia who had mild or moderate iron deficiency anemia were divided into mild group (n = 51) and moderate group (n = 42). Anti-infection and anti-infection plus iron supplementation were given. In the mild group, 27 cases were treated with anti-infective plus iron supplementation (iron supplementation group) and 24 cases were treated with anti-infective alone (control group). In the moderate group, 23 cases were treated with anti-infective plus iron supplementation group and 19 cases in the control group. Observe the anti-infective course of each group, the change of anemia index after the infection improved. Results The treatment course was (9.4 ± 2.2) days in the mild group with anti-infective plus iron supplementation subgroup (9.4 ± 2.2 days) which reached the clinical same node (in line with the evaluation index of clinical improvement), and (10.0 ± 2.0) days in the anti-infective group (P> 0.05). There was no significant difference in anemia index between the 2 subgroups at 3, 7 and 14 days after treatment (P all> 0.05). Median anti-infective plus iron supplementation subgroup reached the same clinical course of treatment (11.3 ± 3.9) d, simple anti-infective group treatment (10.9 ± 4.0) d, the two showed no significant difference (P> 0.05) There was no significant difference in anemia index at 3, 7 and 14 days after treatment (P> 0.05). Conclusion No iron-deficiency anemia caused by Streptococcus pneumoniae was found to be beneficial for iron supplementation. Iron supplementation was not found to have a significant effect on the course of anti-infective treatment.