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寻找满意的骨形态发生蛋白（ＢＭＰ）的载体一直是应用ＢＭＰ修复骨缺损研究中的一个重要课题，为探讨胎儿骨（ＦＢ）能否成为ＢＭＰ载体，制备了复合ＢＭＰ胎儿骨（ＢＭＰ／ＦＢ），将其植入兔桡骨中段１５ｍｍ人工缺损处，以单纯ＦＢ植入、异体骨（ＡＬＢ）植入、空白作为对照，通过Ｘ线摄片，光镜观察，电子探针钙磷元素测定等方法了解各组骨缺损修复速度和愈合程度。结果发现ＢＭＰ／ＦＢ植入侧４周时骨缺损处有大量间充质细胞聚集，８周形成骨小梁，ＦＢ基本被吸收，１２周出现部分板层骨，钙磷值达到正常桡骨皮质骨水平，１６周骨细胞成熟，髓腔再通，外观塑形较好，在不同时间点骨缺损修复程度，ＢＭＰ／ＦＢ组明显优于ＦＢ组，ＦＢ组优于ＡＬＢ组，空白组骨缺损则被纤维组织，脂肪组织等填充。实验证明ＦＢ是一种良好的ＢＭＰ载体。
To find a satisfactory bone morphogenetic protein (BMP) vector has been an important issue in the study of BMP repair using bone morphogenetic protein (BMP) in order to investigate whether fetal bone (FB) can become a BMP vector and prepare BMP / , Which was implanted in the middle of the radius of rabbit radius 15mm artificial defect, simple FB implantation, allogeneic bone (ALB) implantation, blank as a control, by X-ray photography, light microscopy, electronic probe calcium and phosphorus determination Understand the speed of bone defect repair and healing in each group. The results showed that a large number of mesenchymal cells gathered on the bone defect site at 4 weeks after BMP / FB implantation, trabecular bone formed at 8 weeks, FB was basically absorbed, some lamellar bone appeared at 12 weeks, and the calcium and phosphorus values reached normal radius cortical bone At the 16th week, the bone marrow cells matured, the medullary cavity recanalized, and the appearance of the bone was good. At the same time, the bone defect repair level in BMP / FB group was better than FB group, FB group was better than ALB group, Filled with fibrous tissue, adipose tissue, etc. Experiments show that FB is a good BMP vector.