目的了解孕妇应用喹诺酮类药物是否会影响胎儿的软骨发育。方法采用微生物法测定了１０例因感染而口服环丙沙星（ｃｉｐｒｏｆｌｏｘａｃｉｎ，ＣＰＬＸ）的中晚期引产孕妇的血浆、羊水及胎儿血浆、软骨中药物浓度，并观察了胎儿软骨的形态学改变。结果母血、羊水、脐血及胎儿软骨中ＣＰＬＸ浓度分别为１８３、１３５、０６５ｍｇ／Ｌ及１．１１μｇ／ｇ软骨。胎儿软骨结构在光镜下未见明显改变，但超微结构观察发现软骨细胞水肿、退形性变，基质丢失。结论喹诺酮类药物能引起胎儿关节软骨细胞不同程度损伤，孕妇应尽量避免使用喹诺酮类药物 Objective To understand if quinolones used in pregnant women affect fetal cartilage development. Methods The concentrations of plasma, amniotic fluid, fetal plasma and cartilage in 10 middle-late-stage induced labor women who were infected with oral ciprofloxacin (CPLX) were determined by the microbiological method. Morphological changes of fetal cartilage were observed. Results The concentrations of CPLX in maternal blood, amniotic fluid, umbilical cord blood and fetal cartilage were 183,135,065mg / L and 1.11μg / g respectively. Fetal cartilage structure in the light microscope, no significant change, but the ultrastructure observed chondrocyte edema, degeneration, matrix loss. Conclusion Quinolones can cause different degrees of fetal articular cartilage injury, pregnant women should avoid the use of quinolones