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目的 :观察急性脑梗死患者血清同型半胱氨酸(Hcy)水平和其他常见危险因素的变化,并探讨它们之间的相关性。方法:测定392例急性脑梗死血清同型半胱氨酸水平,分为高同型半胱氨酸血症脑梗死组(HHcy脑梗死组)88例及同型半胱氨酸正常脑梗死组(n Hcy脑梗死组)304例,并将其临床特点、血糖、血脂水平、尿酸水平、D-二聚体及糖化血红蛋白水平特点进行回顾性分析。结果:HHcy脑梗死组患者中男性比例多于n Hcy脑梗死组,血清Hcy及糖化血红蛋白水平高于n Hcy脑梗死组,梗死面积较n Hcy脑梗死组大,且均有统计学意义(P<0.05)。相关性分析显示Hcy水平分别与尿酸及D-二聚体水平呈正相关(r值为0.144和0.129,P值均<0.05)。结论:高同型半胱氨酸血症脑梗死发病以男性多见,梗死面积较大,且与尿酸及D-二聚体水平相关。
Objective: To observe the changes of serum homocysteine (Hcy) levels and other common risk factors in patients with acute cerebral infarction and to explore the correlation between them. Methods: Serum homocysteine levels were determined in 392 patients with acute cerebral infarction. The serum homocysteine levels were divided into high homocysteinemia group (88 cases) and homocysteine group (n Hcy group) Cerebral infarction group) 304 cases, and its clinical features, blood glucose, blood lipid levels, uric acid levels, D-dimer and glycated hemoglobin levels were retrospectively analyzed. Results: The proportion of males in HHcy cerebral infarction group was higher than that of nHcy cerebral infarction group, serum Hcy and HbAlc levels were higher than those in nHcy cerebral infarction group, infarct size was larger than nHcy cerebral infarction group (P> <0.05). Correlation analysis showed that Hcy levels were positively correlated with uric acid and D-dimer levels (r = 0.144 and 0.129, P <0.05). Conclusion: The incidence of cerebral infarction with hyperhomocysteinemia is more common in males and larger in infarct size, and is related to uric acid and D-dimer levels.