我们曾合成了一系列铜的大环配合物,在生物体系中有强的SOD活性。为寻求稳定性高且活性也高的Mn-SOD模拟物,我们用Ba~(2+)及Pb~(2+)为模板剂合成了2个新的锰大环和1个锰开环配合物(图1),探讨了其活性和结构的关系,同时还合成了一些锰的羧酸盐配合物与之比较。结果表明,大环配合物的活性比前人作为Mn-SOD模拟物的羧酸盐配合物的高,这为获得Mn-SOD模拟物提供了有益的启示。 We have synthesized a series of copper macrocyclic complexes that have strong SOD activity in biological systems. In order to find Mn-SOD mimics with high stability and high activity, we synthesized two new manganese macrocycles and one manganese open-loop complexes with Ba 2+ and Pb 2+ as templates (Figure 1), the relationship between activity and structure was discussed, and some manganese carboxylate complexes were also synthesized. The results showed that the activity of the macrocyclic complexes was higher than that of carboxylate complexes of Mn-SOD mimics, which provided a useful enlightenment for obtaining Mn-SOD mimics.