A novel purification process based on mixer-settlers for high-purity NdCl_3 was developed. Acidic solution and pure NdCl_3 solution were compared to scrub the less-extractable rare earths(REs)(La, Ce, and Pr)from loaded organic phase. The extractant with low-degree saponification was evaluated to remove the more-extractable element(Sm). Then the RE impurities(La, Ce, Pr, and Sm) in Nd were purified by an integrated process. Furthermore, effect of smuggling behavior on the purification of NdCl_3 in mixersettlers was studied. Based on the investigation mentioned above, the pilot-scale purification process for NdCl_3 with a purity of 99.999% was developed, and the total recovery was about 99%. A novel purification process based on mixer-settlers for high-purity NdCl_3 was developed. Acidic solution and pure NdCl_3 solution were compared to scrub the less-extractable rare earths (REs) (La, Ce, and Pr) from loaded organic phase. The extractant with low-degree saponification was evaluated to remove the more-extractable element (Sm). Then the RE impurities (La, Ce, Pr, and Sm) in Nd were purified by an integrated process. Purification of NdCl_3 in mixers ettlers was studied. Based on the investigation mentioned above, the pilot-scale purification process for NdCl_3 with a purity of 99.999% was developed, and the total recovery was about 99%.