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对于严重肝脏疾病而言,酗酒是首要因素。人体在短时间内摄入大量的酒精,易引起出现急性酒精性肝损伤。本文主要探讨酒精所致肝损伤作用机制的研究进展,首先阐述了乙醇和乙醛的毒性作用,其次,分析了炎症介质和细胞因子的作用,同时,还研究了自由基的损害作用和氧化应激与脂质过氧化作用,具有一定的参考价值。
Alcoholism is the number one factor for serious liver disease. The human body ingestion of a large amount of alcohol in a short time, easily lead to acute alcoholic liver injury. This article mainly explores the research progress of the mechanism of alcohol-induced liver injury. Firstly, the toxic effects of ethanol and acetaldehyde are elucidated. Secondly, the effects of inflammatory mediators and cytokines are analyzed. At the same time, the damaging effects of free radicals and oxidative stress Irritation and lipid peroxidation, has a certain reference value.