论文部分内容阅读
目的探讨血浆脑利钠肽(BNP)、C-反应蛋白(CRP)、血管紧张素Ⅱ(AⅡ)、醛固酮(ALD)在急性脑梗死中的表达及其临床价值。方法测定60例急性脑梗死患者急性期和恢复期血浆BNP、CRP、AⅡ、ALD浓度,并以50例健康体检者作对照。结果急性脑梗死组急性期血浆BNP、CRP、AⅡ、ALD浓度显著高于恢复期(P<0.01)和正常对照组(P<0.01),有高血压病史组血浆BNP、AⅡ含量显著高于无高血压病史组(P<0.01);大面积脑梗死组血浆BNP、CRP显著高于中小面积脑梗死组(P<0.01),大面积脑梗死组血浆AⅡ明显高于中小面积脑梗死组(P<0.05),中面积脑梗死组血浆BNP显著高于小面积脑塞组(P<0.01),大中小面积血浆ALD比较、中小面积血浆AII比较则差异无统计学意义(P>0.05)。结论急性脑梗死患者存在着血浆BNP、CRP、AⅡ、ALD的含量变化,并与病变范围和病情轻重有关,血浆BNP、CRP、AⅡ、ALD可作为急性脑梗死病病情观察的重要指标。
Objective To investigate the expression and clinical value of plasma brain natriuretic peptide (BNP), C-reactive protein (CRP), angiotensin Ⅱ (AⅡ) and aldosterone (ALD) in acute cerebral infarction. Methods Plasma concentrations of BNP, CRP, AII and ALD were measured in 60 acute cerebral infarction patients at acute and convalescent stages. Fifty healthy subjects were used as controls. Results The levels of plasma BNP, CRP, AII and ALD in acute cerebral infarction group were significantly higher than those in recovery phase (P <0.01) and normal control group (P <0.01) (P <0.01). BNP and CRP in large area cerebral infarction group were significantly higher than those in middle and small area cerebral infarction group (P <0.01), while AⅡ in large area cerebral infarction group was significantly higher than that in middle and small area cerebral infarction group (P < (P <0.01). The plasma BNP levels were significantly higher in the middle cerebral infarction group than in the small area cerebral infarction group (P <0.01). There was no significant difference in plasma ALD among the small, medium and large areas (P> 0.05). Conclusion Plasma BNP, CRP, AⅡ and ALD levels in patients with acute cerebral infarction are related to the extent of the disease and the severity of the disease. Plasma BNP, CRP, AⅡ and ALD may be used as important indicators in the observation of acute cerebral infarction.