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Objective: The aim of this study was to observe the efficacy of air wave pressure therapeutic equipment in prevention of oxaliplatin-inducted neurotoxicity. Methods: Forty-five patients with colorectal cancer were randomly divided into treatment group and control group, treatment group were given the treatment of air wave pressure therapeutic equipment during chemotherapy with oxaliplatin, the control group were given preventive treatment, the oxaliplatin-inducted neurotoxicity was evaluated after each cycle of chemotherapy. Evaluate the chemotherapy efficacy after the third cycle and sixth cycle of chemotherapy. Results: The treatment group have lower incidence of peripheral nerve toxicity than the control group, the difference was statistically significant (χ2 = 13.93; P 0.05). Conclusion: Treatment with air wave pressure therapeutic equipment can reduce the incidence of peripheral nerve toxicity during oxaliplatin chemotherapy.