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通过对三株(Ca759,Ca761,Ca763)可移植性乳腺癌带瘤小鼠的双侧腋下与腹股沟区淋巴结、脾脏、胸腺及肿瘤周围间质的组织学动态变化进行比较观察,认为此三组带瘤小鼠免疫形态学的共同变化是;1.淋巴结副皮质区缩小(开始时间各有早晚);2.淋巴结髓质增宽,表现为髓索浆细胞增多,窦组织细胞增生及窦扩张;3.脾红髓增生致脾进行性增大;4.晚期胸腺萎缩。而在三株带瘤宿主中由形态学改变所反映的免疫功能损害各有差别。早期副皮质增生见于Ca759组,不见于Ca761与Ca763组;副皮质区缩小,髓质增宽在Ca761组出现最早,进展最剧,晚期脾白髓萎缩见于Ca761与Ca763组,而不见于Ca759组;胸腺萎缩在Ca761组出现最早,程度显著,而在Ca759组则直到濒死前才发生。本文并分析了淋巴结等免疫器官形态学改变与外周血和肿瘤局部浸润淋巴细胞增减的相关程度及肿瘤本身性质对宿主免疫状态的影响。
By comparing the histological changes of lymph nodes, spleens, thymus and interstitial surrounding stroma of the bilateral axillary and inguinal region in three breast cancer bearing mice with Ca759, Ca761 and Ca763 transplants, it is considered that the three The common morphological changes in mice with tumor-bearing mice were: 1. The paracancerous area of lymph nodes is reduced (the beginning of each time sooner or later); 2. The medullary mass of lymph nodes is broadened, showing the increase of pulp cells, sinusoidal proliferation and sinus Dilation; 3 spleen red pulp proliferative spleen progressive increase; 4. Late thymus atrophy. In the three hosts with tumor morphological changes reflected in the immune dysfunction are different. Early paracortical hyperplasia seen in Ca759 group, not seen in Ca761 and Ca763 group; paracortical area narrowed, medullary enlargement in Ca761 group appeared the earliest, the most dramatic progress, late splenic white pulp atrophy found in Ca761 and Ca763 group, but not in Ca759 group Thymus atrophy appeared the earliest and significant degree in Ca761 group, but not in Ca759 group. In this paper, we analyzed the correlation between morphological changes of immune organs such as lymph nodes and the changes of local infiltration lymphocytes in peripheral blood and tumor and the effect of the nature of tumor on host immune status.