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安徽省在 2 0 0 1、2 0 0 2、2 0 0 4年急性弛缓性麻痹 (AFP)病例监测中 ,有 8例AFP病例粪便标本分离到疫苗变异脊髓灰质炎 (脊灰 )病毒 ,与脊灰疫苗 (Sabin)株相比 ,VP1 区核苷酸差异率为 0 2 2 %～ 0 99%,其中 1例为疫苗衍生脊灰病毒 (VDPV)。 8例主要分布在几个相邻的县 ,年龄主要在≤ 1岁 (7例 ) ,有明显的类似脊灰症状 ,其中 5例未免疫或未全程免疫。密切接触者及周围儿童粪便标本未分离到疫苗变异脊灰病毒 ,当地口服脊灰疫苗 (OPV)接种率调查 ,除 1个村为 4 0 %外 ,其余均 >80 %。表明安徽省局部地区自然环境中存在疫苗变异脊灰病毒的循环 ,但未在人间传播。今后仍应加强儿童OPV常规免疫 ,加强AFP病例监测 ,有计划地开展OPV强化免疫。
In Anhui Province, 8 cases of acute flaccid paralysis (AFP) surveillance in 2000 were isolated from the stool specimens of AFP cases and were isolated from the poliovirus (poliovirus) Compared with the Sabin strain, the nucleotide variation of VP1 region was 0.222% -099%, of which 1 was vaccine-derived poliovirus (VDPV). Eight cases were mainly located in several adjacent counties, mostly aged ≤ 1 year (n = 7) with obvious symptoms similar to polio, of which 5 were uninfected or not fully immunized. Inoculation rate of local oral polio vaccine (OPV) was not more than 80% in 1 case of 40% in one village. Indicating that there is a cycle of vaccine-variant poliovirus in the natural environment in some areas of Anhui Province, but it has not been spread in the world. In the future, routine immunization of children with OPV should still be strengthened, monitoring of AFP cases should be strengthened, and OPV should be intensified in a planned way.