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目的:观察桂枝茯苓丸辅助治疗多囊卵巢综合征(PCOS)伴胰岛素抵抗患者的临床效果。方法:选取110例PCOS伴胰岛素抵抗患者采用随机数字表法分为观察组和对照组各55例,两组患者均采用达英-35、二甲双胍治疗,观察组加用桂枝茯苓丸进行辅助治疗。结果:治疗后两组患者血清LH、FSH、E2、A2、T水平较治疗前均显著改善(P<0.05),且观察组血清LH、FSH、E2、T改善显著优于对照组(P<0.05);治疗后两组患者Fins、HOMAIR、ISI、TC、TG、HDL-C、LDL-C较治疗前均显著改善(P<0.05),且观察组Fins、HOMA-IR、ISI、TC、TG、HDL-C、LDLC改善显著优于对照组(P<0.05);治疗后观察组的多毛和痤疮评分显著低于对照组(P<0.05);两组患者治疗前后BMI、WHR及治疗后1年排卵率、妊娠率及流产率差异无统计学意义(P>0.05)。结论:桂枝茯苓丸辅助治疗PCOS伴胰岛素抵抗较单纯西医疗法能更显著改善患者的胰岛素抵抗及激素水平。
Objective: To observe the clinical effect of Guizhi Fuling Capsule in the treatment of patients with polycystic ovary syndrome (PCOS) and insulin resistance. Methods: 110 cases of PCOS with insulin resistance were randomly divided into observation group and control group with 55 cases in each group. Both groups were treated with Ying Ying-35 and metformin. The observation group was treated with Guizhi Fuling capsule . Results: Serum levels of LH, FSH, E2, A2 and T were significantly improved in both groups after treatment (P <0.05), and the improvement of serum LH, FSH, E2 and T in the observation group was significantly better than that in the control group (P < 0.05). After treatment, Fins, HOMAIR, ISI, TC, TG, HDL-C and LDL-C in both groups were significantly improved compared with those before treatment (P < TG, HDL-C and LDLC in the two groups were significantly better than those in the control group (P <0.05). After treatment, the hairy and acne scores in the observation group were significantly lower than those in the control group (P <0.05) There was no significant difference in ovulation rate, pregnancy rate and abortion rate in one year (P> 0.05). Conclusion: Guizhi Fuling pill adjuvant therapy PCOS with insulin resistance than Western medicine alone can significantly improve the patient’s insulin resistance and hormone levels.