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目的:探讨早产儿肠道饲养对新生儿坏死性结肠炎(NEC)发病机制的影响。方法:选取2011年2月-2014年6月,本院治疗的400例NEC患儿作为研究对象,400例非NEC患儿作为对照组,进行单因素分析及多因素分析。结果:400例NEC患儿中,不同的首次肠道饲养时间、不同的肠道饲养乳制品种类、不同加奶速度的NEC分布均具有有统计学意义(P<0.05);400例NEC患儿中饲养不耐受占80.50%(322例),400例非NEC患儿中饲养不耐受占13.50%(54例);组间比较,差异有统计学意义(P<0.05)。结论:早产儿肠道饲养可作为NEC发病的主要危险因素之一,可通过禁食、抗感染、对症治疗,甚至手术治疗,改善NEC的预后。
Objective: To investigate the effect of intestinal feeding in preterm infants on the pathogenesis of neonatal necrotizing enterocolitis (NEC). Methods: From February 2011 to June 2014, 400 children with NEC treated in our hospital were selected as the research objects and 400 non-NEC children as the control group. Univariate and multivariate analysis were performed. Results: In 400 cases of NEC, there were significant differences (P <0.05) in the distribution of NEC between different feeding durations, different types of dairy products and different feeding rates in 400 cases of NEC Among the non-NEC infants, 80.50% (322 cases) were intolerant and 13.50% (54 cases) intolerant to feeding in 400 cases of non-NEC. There was significant difference between the two groups (P <0.05). CONCLUSIONS: Prenatal gut feeding can be one of the major risk factors for NECs. The effects of fasting, anti-infective, symptomatic treatment and even surgical treatment can improve the prognosis of NEC.