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以交联聚合法制备了环糊精聚合物,对姜黄素(CUR)、去甲氧基姜黄素(DMC)、双去甲氧基姜黄素(BDMC)进行了吸附分离研究。通过荧光光谱法比较了β-环糊精与3种姜黄素类化合物的包结常数(K)。结果表明:环糊精与三者的作用力大小顺序为BDMC>DMC>CUR。考察了环糊精聚合物种类对3种姜黄素类化合物的分离效果,结果表明:环氧氯丙烷交联羟丙基-β-环糊精聚合物(HP-β-CDP1)的吸附选择性最好。以HP-β-CDP1作为吸附剂,进行了单组分动力学研究和等温竞争吸附实验。结果表明:60 min体系达到吸附平衡,吸附动力学符合准二级动力学模型,吸附等温线符合Freundlich等温吸附模型。DMC相对于CUR的分离因子α21为2.1~2.8,BDMC相对于DMC的分离因子α32为2.5~4.1,BDMC相对于CUR的分离因子α31为5.2~11.2,吸附后溶液中CUR、DMC、BDMC的色谱含量分别为88.2%、10%、0.4%。
Cyclodextrin polymers were prepared by the cross-linking polymerization. The adsorption and separation of curcumin (CUR), demethoxycurcumin (DMC) and didemethoxycurcumin (BDMC) were studied. The inclusion constants (K) of β-cyclodextrin and three curcuminoids were compared by fluorescence spectroscopy. The results showed that the order of the acting force between cyclodextrin and three was BDMC> DMC> CUR. The effects of cyclodextrin polymer species on the separation of three curcuminoids were investigated. The results showed that the adsorption selectivity of epichlorohydrin cross-linked hydroxypropyl-β-cyclodextrin polymer (HP-β-CDP1) the best. Using HP-β-CDP1 as adsorbent, single-component kinetics and isothermal competitive adsorption experiments were carried out. The results showed that the adsorption equilibrium was reached after 60 min, the kinetics of adsorption was in accordance with the quasi-second-order kinetic model, and the adsorption isotherm was in accordance with the Freundlich isotherm model. The separation factor α21 of DMC to CUR was 2.1 to 2.8, the separation factor α32 of BDMC to DMC was 2.5 to 4.1, the separation factor α31 of BDMC to CUR was 5.2 to 11.2, and the chromatograms of CUR, DMC and BDMC in the solution after adsorption Contents were 88.2%, 10%, 0.4%.