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碳酸锂对狂躁抑郁症很有治疗价值,但可能引起多种脏器系统毒副作用,有时致死。据报告,严重锂中毒病例中有15%可致死。药理学碳酸锂由胃肠道吸收,2～4小时达血浆峰浓度,5～6日达稳态水平。本品的1/3～1/2在6～12小时内由尿清除,其余在10～14日排出,这与组织(尤其骨)贮存有关。因而,血清水平不能反映体存量。锂离子通过钠、钾转运系统进入红细胞,因而红细胞锂水平能更准确地反映组织浓度。神经症状锂中毒缓慢发生于治疗数日至数周后,
Lithium carbonate is very therapeutic value for Manic Depression, but it may cause side effects of multiple organ systems and sometimes lethal. It has been reported that 15% of severe lithium poisoning cases can be fatal. Pharmacology Lithium carbonate absorbed by the gastrointestinal tract, 2 to 4 hours of plasma peak concentration, 5-6 day steady-state level. This product 1/3 to 1/2 within 6 to 12 hours by the urine clearance, the remaining 10 to 14 days, which is related to tissue (especially bone) storage. Thus, serum levels do not reflect body stock. Lithium ions through the sodium, potassium transport system into the red blood cells, lithium erythrocyte level thus more accurately reflect the tissue concentration. Neurological symptoms Lithium poisoning occurs slowly in the treatment of a few days to several weeks later,