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目的:探讨血清降钙素原(PCT)浓度在新生儿败血症早期诊断中的的临床意义。方法:选择2012年9月至2013年7月我院接收的156例住院新生儿为研究对象,并将其分为3组,非感染组,一般感染组和重度感染组。采用化学发光免疫分析法分别测定156例新生儿血清PCT浓度,并对结果进行对比分析。结果:非感染组新生儿PCT阴性(<0.5μg/L),一般感染组新生儿PCT阳性(0.5～2.0μg/L),重度感染组新生儿PCT阳性(>2.0μg/L),且与非感染组和一般感染组比较均存在显著性差异(P<0.05)。结论:降钙素原检测对新生儿败血症的早期诊断及病情程度判断具体灵敏度高,特异性好、操作简单等优点,可以准确的反映新生儿感染细菌的严重程度,具有重要的临床意义,值得在临床推广应用。
Objective: To investigate the clinical significance of serum procalcitonin (PCT) concentration in the early diagnosis of neonatal sepsis. Methods: A total of 156 hospitalized newborns received in our hospital from September 2012 to July 2013 were selected and divided into three groups: non-infected group, general infection group and severe infection group. Chemiluminescent immunoassay was used to determine serum PCT concentrations in 156 neonates, and the results were compared. Results: The PCT in the noninfected group (<0.5μg / L), PCT in the general infection group (0.5-2.0μg / L) and PCT in the severe infection group (> 2.0μg / L) There was significant difference between non-infected group and general infection group (P <0.05). Conclusion: The detection of procalcitonin can be used to accurately diagnose the severity of neonatal infection of bacteria in the early diagnosis and severity judgment of neonatal sepsis with high sensitivity, good specificity and simple operation. It is of great clinical significance In clinical application.