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细胞ＤＮＡ损伤后 ,需要ＤＮＡ修复系统和细胞周期调控点的协同控制 ,才能维持基因的稳定性。这种控制机制的失常将导致基因的不稳定和肿瘤易感。周期调控点激酶 2 (Ｃｈｅｃｋｐｏｉｎｔｋｉｎａｓｅ 2 ,Ｃｈｋ2 )能通过磷酸化Ｃｄｃ 2 5ｃ的ｓｅｒ2 16残基 ,抑制Ｃｄｃ 2 5ｃ
After DNA damage, DNA repair system and coordinated cell cycle control points are needed to maintain the stability of the gene. Malfunctions in this control mechanism can lead to genetic instability and tumor susceptibility. Checkpoint kinase 2 (Chk2) inhibits Cdc 2 5c phosphorylation by ser216 phosphorylation of Cdc 2 5c