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伯氏疟原虫氯喹敏感株和抗氯喹株感染的RBC,与0.4mmol/L氯喹一起培养2小时后,敏感和抗氯喹株感染的RBC,对[~3H]次黄嘌呤、[~(14)C]精氨酸和[~3H]甲硫氨酸的摄入量分别被抑制67.3％、41.8％和35.7％以及65.4％、45.6和46.9％。 感染疟原虫的小鼠,经氯喹10mg/kg肌注20小时后,各氨基酸组成,在敏感株疟原虫中普遍的较不服药的对照组上升,而在抗氯喹疟原虫中,升高的氨基酸主要是与多胺、谷胱甘肽有关,如精氨酸、鸟氨酸、甲硫氨酸、脯鼠酸、甘氨酸和半胱氨酸。
Chloroquine sensitive strains of Plasmodium berghei and RBC infected with chloroquine resistant strains, RBCs infected with sensitive and chloroquine resistant strains after incubation with 0.4mmol / L chloroquine for 2 hours, were sensitive to [~ 3H] hypoxanthine, [~ (14) C] arginine and [~ 3H] methionine were inhibited by 67.3%, 41.8% and 35.7% and 65.4%, 45.6 and 46.9%, respectively. In mice infected with Plasmodium, each amino acid composition increased by intramuscular injection of chloroquine 10 mg / kg for 20 hours, which was generally higher in the susceptible strain of Plasmodium than in the less-potent control group, whereas in the anti-chloroquine-resistant Plasmodium, elevated amino acids Mainly associated with polyamines, glutathione, such as arginine, ornithine, methionine, mouse acid, glycine and cysteine.