论文部分内容阅读
目的探讨静脉给予ilexgenin A后大鼠体内的药物动力学特征。方法采用HPLC测定大鼠血浆中的血药浓度,用DAS 2.0药动学软件求算其药动学参数。结果 Ilexgenin A在大鼠体内呈二室模型分布,主要药动学参数为:t1/2α=0.545min,t1/2β=18.338 min,Cl=0.019 L·min-1.kg-1,AUC0→t=2.5902 g·min·L-1。结论所用方法可用于大鼠血浆中ilexgeninA的检测及其体内药动学研究;静脉给药后,ilexgenin A在大鼠体内分布和消除迅速。
Objective To investigate the pharmacokinetics of ilexgenin A in rats after intravenous administration. Methods The plasma concentration of rat plasma was determined by HPLC. The pharmacokinetic parameters were calculated by DAS 2.0 pharmacokinetic software. Results Ilexgenin A showed a two-compartment model in rats. The main pharmacokinetic parameters were as follows: t1 / 2α = 0.545 min, t1 / 2β = 18.338 min, Cl = 0.019 L · min-1.kg-1, AUC0 → t = 2.5902 g · min · L-1. Conclusion The method can be used for the detection of ilexgenin A in rat plasma and its in vivo pharmacokinetics. After intravenous administration, ilexgenin A is distributed and eliminated quickly in rats.