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糖尿病肾病(DN)是糖尿病代谢异常引发的肾小球硬化症,是国内外引起终末期肾病的常见病因.研究表明在患有糖尿病肾病的人和动物体内,Klotho的表达均有减少,而通过上调Klotho基因的表达可以明显改善糖尿病肾病的进程,但其中具体的机制仍不清楚.该文就Klotho基因对糖尿病肾病的保护作用机制作一综述.“,”Diabetic nephropathy (DN) is a glomerulosclerosis caused by the metabolic disorder of diabetes mellitus, and is the common cause of end-stage renal disease at home and abroad as well. Studies have shown that there is a decreasing impression of Klotho gene in the body of people or animals with diabetes nephropathy, however, the progression of diabetic nephropathy can be obviously improved by up-regulating Klotho gene expression, but the specific mechanism is still unclear. This assay just makes a review of the protective mechanism of Klotho gene on diabetic nephropathy.