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目的探讨血清IL-1β、IL-8、肿瘤坏死因子-α(TNF-α)及胰岛素样生长因子-1(IGF-1)在新生儿胎粪吸入性肺炎(MAS)发病中的作用。方法采用放射免疫法于生后d1、3、7检测32例MAS患儿及15例正常新生儿血清IL-1βI、L-8、TNF-α及IGF-1水平变化。并对IGF-1与IL-βI、L-8、TNF-α水平变化进行相关性分析。结果MAS患儿出生后3 d内血清IL-1β、IL-8、TNF-α明显增高,与对照组比较有显著差异(P<0.01);至生后d7接近正常对照组水平(P>0.05),而IGF-1生后1周内均明显低于正常对照组水平(P<0.01),且病情越重变化越明显,IGF-1与IL-1β、IL-8、TNF-α水平变化呈明显负相关(r=-0.67,-0.61,-0.73 P均<0.01)。结论新生儿MAS患儿血清IL-1βI、L-8、TNF-α及IGF-1水平的变化与MAS的病情轻重密切相关,可作为病情及评估预后的监测指标。
Objective To investigate the role of serum IL-1β, IL-8, TNF-α and IGF-1 in the pathogenesis of neonatal meconium aspiration pneumonia (MAS). Methods Serum levels of IL-1βI, L-8, TNF-α and IGF-1 in 32 cases of MAS children and 15 normal newborns were detected by radioimmunoassay after birth. The correlation between IGF-1 and IL-βI, L-8 and TNF-α levels was also analyzed. Results The serum levels of IL-1β, IL-8 and TNF-α in MAS children were significantly higher than those in control group within 3 d after birth (P <0.01), and reached the level of normal control group after birth ), While the level of IGF-1 in 1 week after birth was significantly lower than that in the normal control group (P <0.01), and the more severe the changes were, the changes of IGF-1, IL-1β, IL-8 and TNF- There was a significant negative correlation (r = -0.67, -0.61, -0.73 P <0.01). Conclusion The changes of serum IL-1βI, L-8, TNF-α and IGF-1 levels in neonates with MAS are closely related to the severity of MAS, and can be used as the monitoring indicators of the disease and evaluation of prognosis.