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目的:探讨抑郁在帕金森病中(Parkinson’s disease,PD)的发生率及其影响因素。方法:对确诊的PD患者,采用汉密尔顿抑郁量表(Hamilt depression scale,HAMD)、简易精神状态检查量表(Mini-Mental State Examination,MMSE)及Webster功能评分量表进行评定,分析抑郁的发生情况和相关影响因素。结果:PD伴发抑郁者32例,抑郁的发生率为49.2%,病程、文化程度、Webster评分、MMSE评分与帕金森抑郁的发生均有统计学意义(P<0.05),年龄、性别、婚姻状况、经济情况与帕金森抑郁的发生均无统计学意义(P>0.05)。回归分析发现病程和病情严重程度是PD患者抑郁的危险因素。结论:PD患者有较高的抑郁发生率,抑郁的发生可能是社会心理、神经生物学多种因素作用的结果。
Objective: To investigate the incidence of depression in Parkinson’s disease (PD) and its influencing factors. Methods: The diagnosed PD patients were assessed with Hamilt depression scale (HAMD), Mini-Mental State Examination (MMSE) and Webster function scale to analyze the incidence of depression And related factors. Results: There were 32 cases of PD with depression, the incidence of depression was 49.2%. The course of disease, education level, Webster score, MMSE score and depression of Parkinson’s disease were all statistically significant (P <0.05). Age, gender, marriage The status, economic status and the incidence of Parkinson’s depression were not statistically significant (P> 0.05). Regression analysis found that the duration and severity of the disease are risk factors for depression in PD patients. Conclusion: PD patients have a higher incidence of depression, depression may be the result of social psychology, neurobiology and other factors.