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目的 探讨干扰素辅助治疗抽动障碍 (TD)的临床疗效和细胞免疫功能。方法 将 40例患儿按病例编号分为常规组和干扰素组各 2 0例。常规组采用氟哌啶醇、泰必利及安定类药物治疗 ;干扰素组予氟哌啶醇加α2 1b干扰素 (每次 10 0万U ,肌肉注射 ,隔天 1次 )治疗 ,共观察 8周 ,并设 2 0例健康儿童为对照组。采用流式细胞仪测定细胞免疫功能。比较实验前后的临床疗效和免疫功能变化。结果 TD患儿细胞免疫功能明显低于健康对照组。治疗 8周末 ,干扰素组 (10例 )外周血T淋巴细胞亚群和自然杀伤细胞活性较实验前有明显改善 ,治疗有效率为 90 % ,明显高于常规组 (60 % ,χ2 =4 8,P <0 0 5 )。结论 细胞免疫功能紊乱可能与TD有关。干扰素辅助治疗TD ,疗效肯定。
Objective To investigate the clinical efficacy and cellular immune function of interferon adjuvant therapy for tic disorder (TD). Methods 40 cases of children by case number is divided into conventional group and interferon group of 20 cases. The conventional group was treated with haloperidol, tiapride and diazepam. The interferon group was treated with haloperidol plus α2 1b interferon (10 million U each time, intramuscularly and every other day) for observation 8 weeks, and set 20 healthy children as the control group. Cellular immune function was determined by flow cytometry. Before and after comparing the clinical efficacy and immune function changes. Results The cellular immune function in children with TD was significantly lower than that in healthy controls. At the end of the 8th week, the activity of T lymphocyte subsets and natural killer cells in the peripheral blood of the interferon group (10 cases) was significantly improved compared with that before the experiment. The effective rate was 90%, significantly higher than that of the conventional group (60%, χ2 = 48 , P <0 0 5). Conclusion The cellular immune dysfunction may be related to TD. Interferon-assisted treatment TD, curative effect.