Esophageal cancer is a common malignant carcinoma that occurs in the digestive tract and leads to around three million deaths worldwide. Patients commonly present with symptoms, such as dysphagia, cough, hoarseness, and pain in the esophagus. According to researches, smoking, alcohol consumption, exposure to radiation, contaminated food, chronic throat irritation, consumption of extremely hot beverages, genetic mutation, and dystrophia are influential factors in the development of esophageal carcinoma[1]. Diagnostic methods, such as esophagography, endoscopy ultrasonography, positron-emission tomography (PET), and biomarker identification are effective in detecting esophageal cancer. However, the disadvantages of these methods, such as false positive, image blurring, low sensitivity, infection, tissue damage and high cost, may result in misdiagnosis and inconvenience. In addition, the diagnosis of esophageal cancer at an early stage is difficult and has limited sensitivity using common diagnostic approaches.