依据活性亚结构拼接原理,合成了6个新型含有磷酸酯和氨基甲酸酯结构片段的氟虫腈衍生物,其结构经核磁共振氢谱和碳谱、电喷雾质谱(ESI-MS)以及元素分析确证。初步生物活性及毒性测定结果表明:目标化合物对斜纹夜蛾Spodoptera litura和亚洲玉米螟Ostrinia furnacalis幼虫均具有良好的杀虫活性,其中化合物1和2对亚洲玉米螟幼虫的杀虫活性优于氟虫腈,LC50值分别为0.85和2.01μg/mL;目标化合物对意大利蜜蜂Apis mellifera L.的毒性均显著低于氟虫腈。 According to the principle of active substructure splicing, six novel fipronil derivatives containing phosphate and carbamate moieties were synthesized. Their structures were confirmed by 1H-NMR and GC-MS, ESI-MS and elemental analysis Analytical confirmation. The results of preliminary bioassay and toxicity test showed that the target compounds had good insecticidal activity against Spodoptera litura and Ostrinia furnacalis larvae. Among them, the insecticidal activity of compounds 1 and 2 to Larvae of Ostrinia furnacalis was superior to that of Fipronil Nitrile, LC50 values ​​were 0.85 and 2.01μg / mL respectively; the toxicity of the target compound to Apis mellifera L. was significantly lower than that of fipronil.