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目的针对肾移植术后稳定期患者,进行血清半胱氨酸蛋白酶抑制剂C(Cystatin C)和血清肌酐(SCr)的灵敏度的比较。方法在HITACHI-7600-020型自动生化分析仪上采用微粒子颗粒增强透射免疫比浊分析法等方法测定肾移植术后稳定期患者的Cystatin C、SCr等指标。结果对数据用SPSS 11.5软件包进行χ2检验,P<0.01,故可以认为2种检测指标间的差异有统计学意义,即Cystatin C与SCr相比有较好的敏感度。结论血清Cystatin C在稳定期肾移植患者中敏感性与SCr差异存在统计学意义,且优于SCr,能更敏感,更及时的反映GFR的变化,可作为稳定期肾移植患者判断急、慢性排斥和免疫抑制剂的毒性的最重要的观察指标之一。
Objective To compare the sensitivity of serum cystatin C and serum creatinine (SCr) in stable patients after renal transplantation. Methods Cystatin C and SCr were measured in HITACHI-7600-020 automatic biochemical analyzer by particle particle enhanced transillumination immunoassay method. Results The SPSS11.5 software package was used for χ2 test, P <0.01, so the difference between the two test indexes was considered statistically significant, that is, Cystatin C had better sensitivity than SCr. Conclusion The serum level of Cystatin C in patients with stable renal cell transplantation and SCr difference was statistically significant, and better than SCr, can be more sensitive and more timely reflect the changes of GFR, can be used as stable renal transplant patients to determine acute and chronic rejection And one of the most important indicators of toxicity of immunosuppressive agents.