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听神经瘤是源于第Ⅷ对颅神经的良性肿瘤,生长速度慢,可引起听力丧失、面瘫、面部感觉异常甚至脑积水等。外科手术可取得较好的局部控制,但可引起94％病人听力丧失,71％的病人部分或全部单侧面神经功能丧失。自60年代初次用γ刀治疗到现在用直线加速器立体定向放射,取得了满意的局部控制,比外科手术能更多地保存病人的听力、面神经和三叉神经的功能。但γ刀单次大剂量照射缺少分次照射预期的生物学益处,因此作者对直线加速器单次大剂量和分次照射的结果进行了前瞻性分组研究。
Acoustic neuroma is derived from the â ... ¢ benign tumors of the cranial nerves, slow growth, can cause hearing loss, facial paralysis, facial abnormalities or even hydrocephalus. Surgery can achieve better local control, but can cause 94% of patients with hearing loss, 71% of patients with some or all of the unilateral facial nerve function loss. Since the first use of gamma knife treatment in the 1960s to stereotactic radiotherapy with a linear accelerator, satisfactory local control has been achieved, and the patient’s hearing, facial nerve and trigeminal nerve function can be preserved more than surgery. However, a single bolus dose of gamma knife lacks the biological benefits expected from fractionated irradiation. Therefore, the authors conducted a prospective, grouping study of the results of a single bolus and fractional irradiation of a linear accelerator.