肝硬化终末期常并发肾功能的异常,例如肝肾综合征和水盐代谢紊乱。肝病时常可有肾小球形态与功能的变化。既往较注重肝硬化时肾小管的病变,而忽视了肾小球的变化。自1965年广泛开展肾活检以来经光镜、电镜与免疫荧光染色检测,对肝病时肾小球变化有了进一步的认识。病毒性肝炎、感染性疾病、血管炎,红斑狼疮和冷球蛋白血症均可伴有肝和肾小球的病变。在肝硬化伴有肾小球损害的病例中,大多显示系膜IgA沉积,少数为其它免疫球蛋白和C_3的沉积。这些病理改变称为肝硬化肾小球肾炎(Cirrhotic gomerulonephritis,简称CGN)。一、命名自1946年Baxter首先描述肝硬化患者肾小球形态学改变后,早期研究是以尸检为基础的。Horn、 Often terminal liver cirrhosis with renal dysfunction, such as liver and kidney syndrome and water and salt metabolism disorder. Liver disease often have changes in glomerular morphology and function. Previous emphasis on cirrhosis of the renal tubular lesions, while ignoring the glomerular changes. Since 1965, extensive renal biopsy since the light microscope, electron microscopy and immunofluorescence staining, liver disease, glomerular changes have been further understanding. Viral hepatitis, infectious diseases, vasculitis, lupus erythematosus and cryoglobulinemia may be accompanied by liver and glomerular lesions. In cirrhotic patients with glomerular lesions, most of them showed mesangial IgA deposition and a few were deposited with other immunoglobulins and C_3. These pathological changes are called Cirrhotic gomerulonephritis (CGN). I. NAME Since Baxter first described glomerular morphological changes in patients with cirrhosis in 1946, early studies were based on autopsy. Horn,