百草枯中毒诊治:现状与前景

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百草枯(paraquat,PQ)又名克芜踪,属于有机杂环类触杀型除草剂,除草效果好,且对环境、土壤无污染,广泛运用于农业生产中,是我国国内目前使用最为广泛的一种高效、广谱除草剂。但PQ对人剧毒,口服20~40mg/kg PQ水溶液即可致死,如不及时治疗,病死率可高达50%以上~〔1〕。自1966年全世界首例PQ中毒病例被报道以来~〔2〕,PQ中毒已成为医学救治的难点和重点,尤其是在亚太等发展中国家最为显著,近年来,我国PQ中毒呈不断上升趋势~〔3-4〕,虽然我国已禁止PQ生产 Paraquat (PQ), also known as Kewu trace, belongs to the class of organic heterocyclic contact herbicide. It has good weeding effect and is environmentally friendly and soil-free. It is widely used in agricultural production and is currently the most widely used in China An efficient, broad-spectrum herbicide. However, PQ poisoning to people, oral administration of 20 ~ 40mg / kg PQ solution can be fatal, if not treated, the mortality rate can be as high as 50% ~ 〔1〕. Since 1966 the world’s first case of PQ poisoning has been reported 〔2〕, PQ poisoning has become the medical treatment difficulties and priorities, especially in developing countries such as Asia-Pacific most significant, in recent years, China’s PQ poisoning was on the rise ~ [3-4], although China has banned PQ production
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