大多数成人原发性血小板减少性紫癜(ITP)患者用激素、切脾或者免疫抑制剂有效,然而约25%左右的患者对上述方法无效。这些患者病程大于7个月,反复发生血小板减少,严重出血症状,甚至可威胁生命,临床称之原难治性ITP(RITP)。常规方法给以强的松、长春碱、6MP等药物治疗也很少使RITP缓解。1978年Ahn用载有长春花碱的血小板治疗ITP,国内已有类似报道。近年来国外曾有以载有VP—16的血小板治疗RITP成功的报道,而 Most adult patients with idiopathic thrombocytopenic purpura (ITP) are treated with hormonal, splenectomy or immunosuppressive agents, however, about 25% of patients are ineffective with these methods. The duration of these patients is greater than 7 months, recurrent thrombocytopenia, severe bleeding symptoms, and even life-threatening, clinically called the original refractory ITP (RITP). Routine treatment with prednisone, vinblastine, 6MP and other medications rarely reduced RITP. 1978 Ahn platelet containing vinbadum in the treatment of ITP, has been similar to the domestic coverage. In recent years, foreign countries have reported successful treatment of RITP with VP-16 platelets