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目的:探究小剂量波尼松治疗亚急性甲状腺炎的临床效果。方法:本次研究将我院2013年3月~2016年2月收治的100例亚急性甲状腺炎患者纳入研究,采取随机双盲法将所有患者进行均匀分组,对照组(50例)患者采取临床常规药物治疗,研究组(50例)患者则在对照组基础上联合小剂量波尼松治疗,对比两组患者治疗效果、症状消退时间(发热、疼痛、肿胀等)及不良反应情况,并随访半年,观察两组患者疾病复发率。结果:研究组患者治疗总有效率为98.00%,高于对照组86.00%,p<0.05;研究组患者症状消退时间均短于对照组,p<0.05;研究组患者经治疗后疾病复发率较低,为0.00%,显著低于对照组8.00%,p<0.05;两组不良反应率均较低,研究组为4.00%,对照组为2.00%,p>0.05,差异无统计学意义。结论:小剂量波尼松辅助治疗亚急性甲状腺炎的临床效果良好,临床效果明显提升,症状更快改善,不良反应少,复发率低,安全性高。
Objective: To investigate the clinical efficacy of low-dose prednisone in the treatment of subacute thyroiditis. Methods: In this study, 100 patients with subacute thyroiditis admitted to our hospital from March 2013 to February 2016 were enrolled in this study. All patients were evenly divided by randomized double-blind method. The control group (50 patients) The patients in the study group (50 cases) were treated with low-dose prednisone on the basis of the control group, and the treatment effect, symptom subsided time (fever, pain, swelling, etc.) and adverse reactions were compared and followed up Six months, observed two groups of patients with disease recurrence rate. Results: The total effective rate was 98.00% in the study group, 86.00% higher than that in the control group, p <0.05; the symptom subsided time in the study group was shorter than that in the control group, p <0.05; the recurrence rate was higher in the study group than in the control group Low, 0.00%, significantly lower than the control group 8.00%, p <0.05; adverse reactions were lower in both groups, the study group was 4.00%, the control group was 2.00%, p> 0.05, the difference was not statistically significant. Conclusion: The adjuvant treatment of sub-acute thyroiditis with low-dose prednisone has good clinical effect, significantly improved clinical effect, faster improvement of symptoms, fewer adverse reactions, lower recurrence rate and higher safety.