方法和结果:病人均来自Framingham心血管研究人群,男性2 011例,女性2 534例,由进入Framingham研究的第四个2年期作随访起点,随访开始时的年龄为35～70岁。将前四个2年期间的危险因素测值平均后作为今后28年随访期间判断发生远期心性猝死的指标,并以Kaplan-Meier生存曲线及Cox指数模型对预后进行分析。采用logistic回归分析以每2年为期分析危险因素与近期发生心性猝死的关系。在28年的随访中,共171例男性和80例女性发生了心性猝死。在各年龄阶段,女性发生心性猝死的机率均低于男性,即使在对其它已知的危险因素进行校正后,女性发生心性猝死的机率 METHODS AND RESULTS: All patients were from the Framingham Cardiovascular Study population. There were 2 011 males and 2 534 females, ranging from 35 years to 70 years of age at the start of follow-up for the second two-year Framingham study. The average of the risk factors in the first four years of follow-up was used as an indicator of long-term sudden cardiac death during the next 28 years of follow-up. Kaplan-Meier survival curves and Cox index were used to analyze the prognosis. Logistic regression analysis was used to analyze the relationship between risk factors and recent sudden cardiac death. During a 28-year follow-up, sudden cardiac death occurred in 171 males and 80 females. Women of all ages have a lower rate of sudden cardiac death than men, even after correcting for other known risk factors, and the risk of sudden cardiac death in women