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目的探讨术前诱导化疗联合术后放疗治疗Ⅲ、Ⅳ期口腔癌的疗效。方法 48例口腔癌患者随机均分为对照组(给予手术+单纯放疗方案)和治疗组(给予术前诱导化疗+手术+术后放疗方案),比较两组治疗后近期生存率、总有效率和不良反应发生情况。结果治疗组1年生存率(75.0%vs.58.3%)和2年生存率(66.7%vs.45.8%)均高于对照组(P<0.05)。治疗组治疗总有效率高于对照组(83.3%vs.54.2%)(P<0.05)。治疗组白细胞降低、呕吐恶心、放射性皮疹和口腔黏膜受损等不良反应发生率均高于对照组(P<0.05)。结论口腔癌患者联合实施术前诱导化疗和术后放疗能有效提高临床治疗效果,同时能够提高患者近期生存率。
Objective To investigate the effect of preoperative chemotherapy and postoperative radiotherapy for stage Ⅲ and Ⅳ oral cancer. Methods Forty-eight patients with oral cancer were randomly divided into control group (given surgery + radiotherapy alone) and treatment group (given preoperative induction chemotherapy plus surgery plus postoperative radiotherapy). The short-term survival rate, total effective rate And adverse reactions occurred. Results The 1-year survival rate (75.0% vs.58.3%) and 2-year survival rate (66.7% vs.45.8%) in the treatment group were significantly higher than those in the control group (P <0.05). The total effective rate of treatment group was higher than that of control group (83.3% vs.54.2%) (P <0.05). In the treatment group, the incidence of adverse reactions such as leukopenia, vomiting and nausea, radiation rash and oral mucosal injury were all higher than those in the control group (P <0.05). Conclusion Oral cancer patients combined with preoperative induction chemotherapy and postoperative radiotherapy can effectively improve the clinical therapeutic effect, and can improve the short-term survival rate of patients.