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目的:探讨Survivin基因在膀胱癌组织中的表达及临床意义。方法:采用Western-blot方法检测50例膀胱癌组织和22例正常膀胱黏膜中Survivin蛋白的表达。结果:Survivin蛋白在50例膀胱癌中阳性表达率为(81.0%),在22例正常膀胱黏膜中均无表达。在浸润性膀胱癌中(96.3%)较浅表性膀胱癌中(65.2%)显著升高(P<0.01);在复发性膀胱癌中(93.3%)较初发膀胱癌中(65.0%)显著升高(P<0.05)。结论:Survivin基因在膀胱癌组织中的表达量远远高于正常膀胱组织,其表达量还可用来预测膀胱癌的复发和浸润。
Objective: To investigate the expression of Survivin gene in bladder cancer and its clinical significance. Methods: Survivin protein was detected by Western-blot in 50 cases of bladder cancer and 22 cases of normal bladder mucosa. Results: The positive rate of Survivin protein in bladder cancer was 50% (81.0%), which was not found in 22 cases of normal bladder mucosa. (96.3%) in superficial bladder cancer (65.2%) (P <0.01); in recurrent bladder cancer (93.3%) than in primary bladder cancer (65.0%), Significantly increased (P <0.05). Conclusion: The expression of Survivin gene in bladder cancer is much higher than that in normal bladder tissue. The expression level of Survivin can be used to predict the recurrence and invasion of bladder cancer.