系统性硬皮病(SSc)是一种全身性结缔组织病,以皮肤和某些内脏器官中胶原的过度聚集为特征。胶原是真皮的主要成分之一,它主要由成纤维细胞产生,其合成是组织再生、纤维化的重要步骤。目前已知某些细胞因子,如转化生长因子-β,白介素-1,γ-干扰素及肿瘤坏死因子-α(TNF-α)对胶原的代谢有特殊的作用。其中,由巨噬细胞合成的TNF-α在胶原的代谢中发挥最重要的调节作用。 Systemic scleroderma (SSc) is a systemic connective tissue disease characterized by excessive aggregation of collagen in the skin and certain internal organs. Collagen is one of the main components of the dermis, which is mainly produced by fibroblasts. Its synthesis is an important step of tissue regeneration and fibrosis. It is known that certain cytokines such as transforming growth factor-β, interleukin-1, interferon-γ and tumor necrosis factor-α (TNF-α) have a special effect on the metabolism of collagen. Among them, TNF-α synthesized by macrophages plays the most important regulatory role in the metabolism of collagen.