内毒素脂多糖 (L PS)可激活单核 /巨噬细胞 ,产生一系列炎症反应 ,而 L PS跨膜信号转导是引起细胞效应的关键。本文主要综述 L PS结合蛋白 (L BP) ,L PS受体 (m CD14、s CD14 )以及 Toll样受体 (TL Rs)在 L PS激活细胞及信号跨膜传递中的重要作用。推测 L PS/L BP与细胞膜 CD14结合后 ,TL Rs以细胞外富含亮氨酸片段的重复序列识别 L PS,将 L PS的刺激信号跨膜转导 ,激活 NF- κB信号途径导致效应基因的表达 Endotoxin lipopolysaccharide (LPS) activates monocytes / macrophages and produces a series of inflammatory responses, whereas LPS transmembrane signal transduction is the key to cellular effects. This article reviews the important role of LPS-binding protein (LBP), LPS receptor (mCD14, CD14) and Toll-like receptor (TLRs) in LPS-activated cells and signal transduction. It is speculated that upon binding of LPS / L BP to the cell membrane CD14, TLRs recognize LPS with a repeating sequence rich in extracellular leucine fragments, transduce the stimulatory signal of LPS across the membrane, and activate the NF- [kappa] B signaling pathway leading to effector genes expression