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对纤维胃镜活检的胃粘膜腺体扩张标本进行了形态观察，并采用ＳＰ免疫组化方法，观察ＥＧＦＲ和ＰＣＮＡ的表达。结果ＥＧＦＲ在胃粘膜单纯性腺体扩张中，仅有１９％的弱阳性表达，在异型性腺体扩张中，阳性表达为５３．８％，有显著性差异（Ｐ＜０．０１）。胃腺癌阳性表达７６．３％，与异型性腺体扩张比较无显著性差异（Ｐ＞０．０５）。ＰＣＮＡ在单纯性腺体扩张中阳性细胞数平均值为１９．２个，在异型性腺体扩张中，平均值为４５个，二者有非常显著性差异（Ｐ＜０．０１）。胃管状腺癌阳性细胞平均值为５８．１个，与异型性腺体扩张比较无显著性差异（Ｐ＞０．０５）。提示ＥＧＦＲ和ＰＣＮＡ表达均随细胞的异型性程度增加而递增，二者有显著的相关性。对胃粘膜良、恶性病变的诊断和鉴别有实用价值，联合检测可提高诊断的准确率。异型性腺体扩张是重要的癌前病变。
The gastric mucosal glandular dilatation specimens were observed by fiberoptic endoscopy biopsy. SP immunohistochemistry was used to observe the expression of EGFR and PCNA. RESULTS: In the simple glandular dilatation of gastric mucosa, EGFR showed weak positive expression only in 19%, and in heterotypic gland dilation, the positive expression was 53.8%, with significant difference (P<0.01). The positive expression of gastric adenocarcinoma was 76.3%, which was not significantly different from that of atypical glands (P>0.05). The average number of positive cells in the simple glandular expansion of PCNA was 19.2, and in the abnormal glandular expansion, the average was 45, and there was a very significant difference between the two (P<0.01). The average number of gastric tubular adenocarcinoma positive cells was 58.1, which was not significantly different from that of atypical glands (P>0.05). It was suggested that the expression of EGFR and PCNA increased with the degree of heteromorphism of the cells, and there was a significant correlation between them. It has practical value in the diagnosis and identification of benign and malignant lesions of gastric mucosa. Joint detection can improve the accuracy of diagnosis. Abnormal gland expansion is an important precancerous condition.