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目的 比较乳癌病人血清 p5 3抗体和组织 p5 3表达之间的关系。方法 6 8例乳癌病人血清 p5 3抗体用酶联免疫法 (EL ISA)检测 ,组织 p5 3蛋白用免疫组织化学法检测。结果 6 8例乳癌病人血清 p5 3抗体阳性 19例 ,阳性率 2 8% ,组织 p5 3阳性 2 7例 ,阳性率 4 0 % ,组织 p5 3阳性同时血清 p5 3抗体阳性者 14例 ,组织 p5 3阳性而血清 p5 3抗体阴性者 13例 ,组织 p5 3阴性但血清 p5 3抗体阳性者 5例。结论 组织和血清之间具有密切相关性 ,但非完全一致 ,p5 3抗体的检测更是一个预测乳癌复发或高危险性的指标。
Objective To compare the relationship between serum p5 3 antibody and tissue p5 3 expression in breast cancer patients. Methods Sixty-eight cases of breast cancer patients with serum p5 3 antibody by enzyme-linked immunosorbent assay (EL ISA) detection, tissue p5 3 protein was detected by immunohistochemistry. Results The positive rate of serum p5 3 antibody in 68 cases of breast cancer patients was 19, the positive rate was 28%, the positive rate of p5 3 was 27, the positive rate was 40%. The positive rate of p5 3 in serum was 13 3 positive and serum p5 3 antibody negative in 13 cases, tissue p5 3 negative but serum p5 3 antibody positive in 5 cases. Conclusion There is a close correlation between tissue and serum, but not completely. The detection of p5 3 antibody is more an index to predict the recurrence or risk of breast cancer.