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目的探讨聚焦超声治疗绝经后外阴上皮内非瘤样病变的治疗方案。方法将绝经后外阴上皮内非瘤样病变106例患者随机分为聚焦超声单次治疗组(53例)与多次治疗组(53例)。在治疗期间及治疗后,观察病变部位的症状及体征,进行疗效及不良反应评价。结果多次治疗组治愈率(62.26%)显著高于单次治疗组(33.96%)(P<0.01),其中多次治疗组苔癣型治愈率(80%)显著高于单次治疗组(36.36%)(P<0.01),多次治疗组不良反应发生率(8.93%)显著低于单次治疗组(30%)(P<0.01)。结论聚焦超声多次治疗较单次治疗绝经后外阴上皮内非瘤样病变更有效、更安全。
Objective To investigate the treatment of non-neoplasia lesions in post-menopausal vulvar epithelium by focused ultrasound. Methods One hundred and sixty-six patients with intra-vulvar intravaginal non-tumorous lesion were randomly divided into single-ultrasound group (53 cases) and multiple-treatment group (53 cases). During the treatment and after treatment, observe the signs and symptoms of the lesion, the efficacy and adverse reaction evaluation. Results The cure rate of multiple treatment group (62.26%) was significantly higher than that of single treatment group (33.96%) (P <0.01), and the cure rate of multiple lichenification in multiple treatment group was significantly higher than that of single treatment group 36.36%) (P <0.01). The incidence of adverse reactions in multiple treatment group (8.93%) was significantly lower than that in single treatment group (30%) (P <0.01). Conclusions Multi-treatment with focused ultrasound is more effective and safer than single treatment of non-xenograft vulvar intraepithelial lesion.