骨髓是多能造血干细胞的来源,可产生粒细胞、红细胞和淋巴细胞等所有血细胞成份。人们一般多采用鼠类骨髓干细胞,维持其在培养基中生长和分化数周的方法研究造血途径和调节机制。体外已可以使原始细胞分化成为粒细胞,巨核细胞和红细胞,但仍未见到使鼠骨髓细胞分化成淋巴细胞。作者报告一种同种效应因子(allogeneic effect factor,AEF),能诱导小鼠骨髓细胞中T细胞生长。AEF是先用同种抗原在鼠体内激活T细胞,取出后,第二次混合淋巴细胞培养产生的可溶性介质,是 Bone marrow is a source of pluripotent hematopoietic stem cells that produce all blood cell components such as granulocytes, red blood cells, and lymphocytes. People generally use more mouse bone marrow stem cells, maintain their growth and differentiation in the medium for several weeks to study hematopoietic pathway and regulatory mechanisms. In vitro, primitive cells have been able to differentiate into granulocytes, megakaryocytes and erythrocytes, but no differentiation of murine bone marrow cells into lymphocytes has been observed. The authors report that an allogeneic effect factor (AEF) can induce T cell growth in mouse bone marrow cells. AEF is the first with alloantigen in mice activated T cells, removed after the second mixed lymphocyte culture produced by the soluble medium is