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[目的]探讨双歧杆菌四联活菌、甘草锌联合消旋卡多曲治疗轮状病毒感染腹泻的效果及对患儿血清炎症因子和心肌酶谱的影响.[方法]选取2017年3月至2018年10月在本院接受治疗的136例轮状病毒感染腹泻患儿为研究对象,随机分为对照组和观察组各68例.对照组患儿给予双歧杆菌四联活菌、甘草锌治疗,观察组患儿在对照组治疗的基础上联合消旋卡多曲治疗,两组均连续治疗3 d.比较两组患儿临床症状和体征改善时间(退热时间、脱水纠正时间、大便恢复正常时间、病毒转阴时间等) ,血清炎症因子指标[白介素6(IL‐6)、肿瘤坏死因子α(TNF‐α) 、C反应蛋白(CRP)]以及血清心肌酶谱指标[血清乳酸脱氢酶(LDH) 、磷酸肌酸激酶(CK) 、磷酸肌酸激酶同工酶(CK‐MB) 、α‐羟基丁酸脱氢酶(HBDH )]的变化;并比较两组治疗疗效.[结果]治疗前,两组各观察指标比较,差异无统计学意义( P ＞0 .05).治疗后,观察组临床症状和体征改善时间(退热时间、脱水纠正时间、大便恢复正常时间、病毒转阴时间等)短于对照组( P ＜0 .05) ;两组血清炎症因子指标(IL‐6 、T NF‐α 、CRP)以及心肌酶谱指标(LDH 、CK 、CK‐MB 、HBDH )较同组治疗前均有改善,且观察组改善程度优于对照组( P ＜0 .05) ;观察组治疗总有效率高于对照组( P ＜0 .05).[结论]双歧杆菌四联活菌、甘草锌联合消旋卡多曲治疗小儿轮状病毒感染腹泻能提高临床疗效,改善病情转归,缓解患儿临床症状和体征,减轻炎症反应程度,降低心肌酶谱水平,值得临床推广应用.“,”To investigate the effect of Bifidobacterium tetrad living bacteria ,zinc Glycyrrhiza com‐bined with racecadotril in the treatment of diarrhea caused by rotavirus infection and the effect on serum inflamma‐tory factors and myocardial enzymes in children .[M ethods]A total of 136 children with diarrhea due to rotavirus infection w ho were treated in our hospital from M arch 2017 to October 2018 were randomly divided into control group and observation group with 68 cases in each group .T he control group was treated with live Bifidobacterium tetrad and zinc glycyrrhiza .T he observation group was treated with racecadotril on the basis of the control group . Both groups were treated for 3 days .T he improvement time of clinical symptoms and signs (antifebrile time ,de‐hydration correction time ,stool recovery time ,virus negative time ,etc.) and serum inflammatory factors (IL‐6 , T NF‐alpha ,CRP) and serum myocardial enzymes (LDH ) were compared between the two groups .T he changes of creatine phosphate kinase (CK ) ,creatine phosphate kinase isoenzyme (CK‐MB) and alpha‐hydroxybutyrate dehy‐drogenase (HBDH ) were compared between the two groups .[Results]Before treatment ,there was no significant difference in the observation indexes between the two groups ( P ＞0 .05).After treatment ,the improvement time of clinical symptoms and signs (antipyretic time ,dehydration correction time ,stool recovery time ,virus negative time) in the observation group was shorter than that in the control group ( P ＜0 .05) ;the indexes of serum in‐flammatory factors (IL‐6 ,T NF‐a ,CRP ) and myocardial zymogram (LDH ,CK ,CK‐MB , HBDH ) in the two groups were improved compared with those in the same group before treatment .T he improvement degree of the observation group was better than that of the control group ( P ＜0 .05) ,and the total effective rate of the observa‐tion group was higher than that of the control group ( P ＜0 .05).[Conclusion]Bifidobacterium tetrad ,zinc Gly‐cyrrhiza combined with racecadotril in the treatment of infantile rotavirus‐infected diarrhea can improve the clinical efficacy ,improve the prognosis of the disease ,alleviate the clinical symptoms and signs of children ,reduce the de‐gree of inflammation ,reduce the level of myocardial enzymes ,w hich is worthy of clinical application .