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目的评价阻塞性睡眠呼吸暂停综合征(OSAS)正常糖耐量(NGT)患者持续正压通气(CPAP)治疗前后胰岛β细胞功能和胰岛素抵抗情况。方法对35例OSAS正常糖耐量(NGT)患者CPAP治疗前后,全部行口服葡萄糖耐量试验,计算治疗前后早时相胰岛素生成指数和胰岛素抵抗指数。结果 OSAS NGT患者CPAP治疗后患者早时相胰岛素生成指数上升(P<0.05),胰岛素抵抗指数下降(P<0.05)。结论 OSAS患者经过CPAP治疗后能改善胰岛素分泌,减轻胰岛素抵抗。
Objective To evaluate the effects of continuous positive pressure ventilation (CPAP) on pancreatic β-cell function and insulin resistance in patients with obstructive sleep apnea syndrome (OSAS) with normal glucose tolerance (NGT). Methods 35 patients with OSAS normal glucose tolerance (NGT) before and after CPAP were treated with oral glucose tolerance test, and the indexes of early phase insulin production and insulin resistance before and after treatment were calculated. Results In patients with OSAS NGT, the early phase insulin production index (P <0.05) and the insulin resistance index decreased (P <0.05) after CPAP treatment. Conclusion After CPAP treatment, OSAS patients can improve insulin secretion and reduce insulin resistance.