替吉奥致严重泪道阻塞的临床病例分析

来源 :药物不良反应杂志 | 被引量 : 0次 | 上传用户:paokahh
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的:探讨替吉奥(S-1)引起严重泪道阻塞患者的临床特征、治疗及预后。方法:对2017年1月至2019年1月在解放军总医院第三医学中心眼科泪器病中心住院手术治疗的S-1相关严重泪道阻塞患者临床及随访资料进行回顾性分析。结果:共有12例患者纳入本研究,男性7例,女性5例,年龄(53±8)岁;口服S-1时间为(4.1±1.1)个月,从开始服用S-1至溢泪症状出现的时间为(53.3±31.2)d。12例患者均为双眼患病(12例,24眼),同时出现上下泪小管阻塞(12例,24眼,48个泪小管),其中45个泪小管(93.8%)重度阻塞,3个泪小管(6.2%)中度阻塞。2例患者双眼上下泪小管的泪点(8个)完全闭锁。12例患者中8例双眼(16眼)同时并发鼻泪管完全阻塞,4例患者双眼(8眼)同时并发鼻泪管不完全阻塞。8例患者接受泪道内窥镜下泪道激光成形术联合双泪小管置入式人工泪管置入术,取管后5例溢泪减轻,3例无好转。2例接受泪囊切开逆行探查疏通泪小管联合双泪小管置入式人工泪管置入术,取管后溢泪减轻。2例接受泪囊切开逆行探查疏通泪小管联合泪囊鼻腔吻合术及双泪小管置入式人工泪管置入术,取管后溢泪症状改善明显,仅有轻度溢泪。结论:S-1所致严重泪道阻塞以广泛性多部位阻塞为特征,选择合适的手术治疗,部分患者溢泪症状好转。“,”Objective:To explore the clinical characteristics, treatment and prognosis of patients with severe lacrimal duct obstruction caused by tegafur-gimeracil-oteracil potassium (S-1).Methods:The medical records and follow-up data of the surgical inpatients with severe lacrimal duct obstruction caused by S-1 in Lacrimal Center of Ophthalmology, the Third Medical Center of Chinese PLA General Hospital from January 2017 to January 2019 were analyzed retrospectively.Results:A total of 12 patients were enrolled in this study, including 7 males and 5 females, aged (53±8) years. The time of oral administration of S-1 was (4.1±1.1) months, and the time from the beginning of administration of S-1 to the onset of epiphora symptoms was (53.3±31.2) days. All the 12 patients had binocular diseases (involving 12 cases, 24 eyes) and obstruction of both upper and lower lacrimal canaliculi (involving 48 lacrimal canaliculi). Among the 48 obstructed lacrimal canaliculi, 45 (93.8%) were severe, and 3 (6.2%) were moderate. The 8 lacrimal points of the upper and lower lacrimal canaliculi in both eyes of the 2 patients were completely atresic. In 12 patients, 16 eyes in 8 patients were complicated with complete obstruction of nasolacrimal ducts and 8 eyes in the other 4 patients were complicated with incomplete obstruction of nasolacrimal ducts. Eight patients underwent laser dacryoplasty combined with bicanalicular intubation assisted by lacrimal canaliculus micro-endoscopy. After taking off the tubes, epiphora was relieved in 5 patients but not improved in the other 3 patients. Two patients underwent retrograde exploration to probe canaliculi transdacryocyst combined with bicanalicular intubation. After taking off the tubes, epiphora was relieved. Two patients underwent retrograde exploration to probe canaliculi transdacryocyst combined with dacryocystorhinostomy. After taking off the tubes, epiphora was improved obviously and only slight epiphora was found.Conclusions:Severe lacrimal duct obstruction caused by S-1 was characterized by extensive multiple obstruction. Appropriate surgical treatment can improve the symptoms of epiphora in some patients.
其他文献
混凝土面板堆石坝是近二、三十年发展起来的一种新坝型,具有断面小、安全性好、就地取材、施工方便、工期短、适应性强、取价低等优点,是目前世界各国选用较多的一种坝型,深
近年来,诸多学者对于《矿井地质规程》中,以煤层厚度变异系数、煤层可采性指数作为煤层厚度稳定性评价指标提出疑问,认为这两个指标并不能完整的体现出煤层厚度的变化特点,因
目的:了解丙泊酚联合舒芬太尼麻醉行无痛清宫术患者术中记忆(梦、幻觉和术中知晓)的发生状况并分析其影响因素。方法:对2017年1月至2018年9月在双桥医院应用丙泊酚联合舒芬太尼
研究区位于杭锦旗东北部,以泊尔江海子断裂为界,断裂南、北差异大,北部构造位置位于伊蒙隆起北部杭锦旗断阶带上,发育向西南倾没的鼻状隆起和几个小型构造隆起,南部位于伊陕