13-Methyltetradecanoic acid can stabilize cell membrane and have anti-inflammatory,antioxidant and anti-apoptotic effects.Previous studies mainly focused on peripheral nerve injury,but seldom on the central nervous system.We investigated whether these properties of 13-methyltetradecanoic acid have a neuroprotective effect on focal cerebral ischemia/reperfusion injury,and detected the expression of basic fibroblast growth factor and vascular endothelial growth factor.This study established rat models of middle cerebral artery occlusion/reperfusion injury by ischemia for 2 hours and reperfusion for 24 hours.At the beginning of reperfusion,13-methyltetradecanoic acid 10,40 or 80 mg/kg was injected into the tail vein.Results found that various doses of 13-methyltetradecanoic acid effectively reduced infarct volume,mitigate cerebral edema,and increased the m RNA and protein expression of basic fibroblast growth factor and vascular endothelial growth factor at 24 hours of reperfusion.The effect was most significant in the 13-methyltetradecanoic acid 40 and 80 mg/kg groups.The findings suggest that 13-methyltetradecanoic acid can relieve focal ischemia/reperfusion injury immediately after reperfusion,stimulate the upregulation of basic fibroblast growth factor and vascular endothelial growth factor to exert neuroprotective effects. 13-Methyltetradecanoic acid can stabilize cell membrane and have anti-inflammatory, antioxidant and anti-apoptotic effects. Previous studies mainly focused on peripheral nerve injury, but seldom on the central nervous system. We investigated whether these properties of 13-methyltetradecanoic acid have a neuroprotective effect on focal cerebral ischemia / reperfusion injury, and detected the expression of basic fibroblast growth factor and vascular endothelial growth factor. This study established rat models of middle cerebral artery occlusion / reperfusion injury by ischemia for 2 hours and reperfusion for 24 hours. At the beginning of reperfusion, 13-methyltetradecanoic acid 10,40 or 80 mg / kg was injected into the tail vein. Results found that the various doses of 13-methyltetradecanoic acid effectively reduced infarct volume, mitigate cerebral edema, and increased the m RNA and protein expression of basic fibroblast growth factor and vascular endothelial growth factor at 24 hours of reperfusion ect was most significant in the 13-methyltetradecanoic acid 40 and 80 mg / kg groups. The findings suggest that 13-methyltetradecanoic acid can relieve focal ischemia / reperfusion injury immediately after reperfusion, stimulate the upregulation of basic fibroblast growth factor and vascular endothelial growth factor to exert neuroprotective effects.